One of the early, non-financial uses of blockchain technologies around which several startups have developed was to help manage, monetize, and make the sharing of genomic data more private. Because deidentified genomic data are excluded from HIPAA and many other regulatory contexts worldwide—and is already a widely traded commodity for science valued in the hundreds of millions over the past decade—genomic blockchains proved a promising entry point for using the benefits of blockchains for dissemination and remuneration of data. Several models (...) have been tried, and most have touted their abilities to make users the “owners” of the genomic data in ways in which current models fail. This paper will explore the various existing and potential models for genomic blockchains, review some shortcomings and unmet needs, and explain why no technical solution alone will fulfill the promise of genomic data ownership without regulation. (shrink)

The universally recognized backbone of molecular biology describes the flow of genetic information from deoxyribonucleic acid (DNA) to ribonucleic acid (RNA) to protein or gene product, that is, DNA is transcribed into another nucleic acid (RNA), which is single stranded, next some types of RNA are in turn translated into proteins. Translation of nucleic acids to proteins is literally a translation from the genomic language to the metabolic language. Codons formed of a sequence of three nucleic acids summon a specific (...) amino acid. Translation from codons to proteins, that is, protein synthesis, takes place by specialized machinery comprising mRNA, ribosomes, and free amino acids. Inferring the structure of DNA opened the door for tremendous advances in understanding the role of genes in creating life, directing replication, and ongoing metabolic processes responsible for maintaining life at both the cellular and organism level. (shrink)

El enorme desarrollo que en las últimas décadas han experimentado las tecnologías de la computación y las comunicaciones ha provocado diversos debates teóricos y dilemas éticos entre los que la perspectiva de género ha permanecido tradicionalmente ausente. Algunos análisis feministas sobre tecnologías digitales han surgido dentro de la corriente CTS, siendo mucho más escasos en el ámbito de la ética computacional En este trabajo expondremos la historia de la perspectiva de género en los estudios sobre tecnologías computacionales, y mostraremos la (...) pertinencia y la importancia de esta perspectiva para una adecuada comprensión del fenómeno, tanto desde el punto de vista de la relación entre tecnología y sociedad, como de los problemas éticos de los que se ocupa la ética computacional. (shrink)

John Locke's philosophy was deeply affected by medicine of his times. It was specially influenced by the medical thought and practice of Thomas Sydenham. Locke was a personal friend of Sydenham, expressed an avid interest in his work and shared his views and methods. The influence of Sydenham's medicine can be seen in the following areas of Locke's philosophy: his “plain historical method”; the emphasis on observation and sensory experience instead of seeking the essence of things; the rejection of hypotheses (...) and principles; the refusal of research into final causes and inner mechanisms; the ideal of irrefutable evidence and skepticism on the possibilities of certainty in science. The science which for Locke held the highest paradigmatic value in his theory of knowledge was precisely medicine. To a great extent, Locke's Essay on Human Understanding can be understood as an attempt to justify, substantiate, and promote Sydenham's medical method. This method, generalized, was then proposed as an instrument for the elaboration of all natural sciences. (shrink)

La fraternidad es una idea política con una larga trayectoria histórica y forma parte del nacimiento de la política moderna durante el período de la Revolución francesa junto a las ideas de libertad e igualdad. No obstante, la fraternidad ha recibido muy poca atención por parte de la filosofía política contemporánea. En este artículo, realizo un análisis conceptual de la idea política de fraternidad con el fin de identificar los elementos comunes y distintivos de la misma.

El artículo trata de aplicar las concepciones gramscianas al estudio de la primera constitución española. En el análisis se observan cuestiones relacionadas con la educación y los grupos hegemónicos intentando aportar nuevos datos tras la interpretación.

In the last decades, the evidence-based approach has become dominant in the biomedical sciences. Its influence has extended from clinical practice to other areas such as drug regulation and public health. Nonetheless, given the limitations of the evidence-based framework, a more pluralist approach towards evidence has been demanded. In this sense, evidential pluralism holds that evidence of mechanisms should complement statistical evidence. This paper aims to explore and discuss the prospects of evidential pluralism in public health. First, we will analyse (...) the evidential standards of the International Agency for Research on Cancer. Those standards are argued to be in line with the pluralist approach. Second, we will consider the main challenges for gathering evidence of mechanisms in public health. For that purpose, diverse types of evidence of mechanisms will be identified. And third, we will assess the role of agent-based models as mechanistic studies. Based on a case study, we will discuss whether agent-based models can provide evidence of mechanisms and mitigate the abovementioned challenges. (shrink)

Axiological foundations of free speach. Belandria, Margarita y González R., Javier Voluntad, ausencias, y normas: el sustrato histórico del positivismo en el derecho. Will, absences and norms: the historical background of positivism in law. Carpintero Benítez, Francisco Nominalismo jurídico, escolástica española y tradición republicana. Juridical nominalism, spanish scholasticism and republican tradition. Casanova Guerra, Carlos El primer principio de la razón práctica en la teoría de la ley natural de John Finnis. The first principle of practical reason in John Finnis´s natural (...) law theory. Hocevar G., Mayda G. El derecho a una educación integral de calidad, ¿utopía o posibilidad?. The right to an integral education of quality: utopia or possibility?. López de Cordero, Mery La muerte de la imagen. The death of the image. Peña, Edilio Karl Jaspers: autorreflexión y "existenzerhellung". Karl jaspers: self-reflection and "existenzerhellung". Portuondo Pajón, Gladys L. Derechos humanos y positivismo moderado. Human rights and temperated positivism. Ramos Pascua, José Antonio De la libertad y sus apariencias. On liberty and its appearances. Ramis Muscato, Pompeyo Pensamiento y vida: la "guía" zambraniana. Thought and life: zambrano's "guide" Rivara Kamaji, Greta Interdisciplinares Las mujeres en la ciencia de la salud. Women in the health sciences. Alcaraz Ariza, María Ángeles Cultura arquitectónica y crisis de la contemporaneidad. Architectural culture and crisis of the contemporary. Arellano Spinetti, Leonardo Recensiones Homenaje al filósofo venezolano Alberto Rosales. Walton, Roberto Informaciones Índice acumulado. (shrink)

Brings together a range of practitioners and academics from the world of business who examine corporate social responsibility in policy and practice in a series of case studies from across the globe.

Este artículo analiza ciertas interpretaciones del célebre comentario de Wittgenstein a Drury, sin duda relevantes para comprender el sentido de la filosofía del pensador vienés en su último periodo, según el cual él mismo, sin ser una persona religiosa, no podía evitar contemplar todas las cuestiones desde una perspectiva religiosa. Los pasos para identificar la razón por la que se puede afirmar que la inmunización de la forma de vida religiosa constituye el sentido último de la filosofía concebida como análisis (...) de los juegos de lenguaje serán, en primer lugar, poner en relación el valor supremo de la claridad con la crítica de la actitud explicativa característica de la filosofía convencional y, en segundo término, considerar el análisis del discurso religioso y la peculiar religiosidad del propio Wittgenstein. This paper explores some of the issues related to Wittgenstein's famous comment to Drury -that he himself, while not a religious person, could not avoid contemplating all questions from a religious perspective- that might contribute to an understanding of the final meaning of the philosophical practice distinctive of Wittgenstein's last period. This paper aims at showing that final meaning is the immunization of the religious form of the life. In order to reach this conclusion we will first recall the importance of clarity as an absolute goal of Wittgenstein's philosophy, and see how it is connected to a specific attitude toward the explanatory claims of conventional philosophy. Then we will summarize the essence of Wittgenstein's philosophical analysis of religious discourse and review some crucial texts that highlight the peculiar religiosity unique to Wittgenstein. (shrink)

This paper seeks to highlight the various interpretations that, before the Second Council of Constantinople, many Latin Church Fathers gave on several metaphorical expressions, such as “God’s temple,” “sanctuary,” “tabernacle,” “ark,” and other similar terms referring to spaces or containers reserved for deity. To address this issue, the author of this article structures his methodology on three strategies: the first consists in a profound tracking in Patristic and theological sources to detect some relevant statements by conspicuous Christian masters on the (...) subject; through the second, he analyzes intra-textually each found Patristic assertions to decipher the doctrinal interpretation that every Christian writer brings about such metaphors; by the third methodological strategy, he intertextually relates all these texts, and authors through a comparative analysis to highlight their possible concordances or discrepan- cies. Resumen Este artículo busca resaltar las diversas interpretaciones que, antes del Segundo Concilio de Constantinopla, muchos Padres de la Iglesia Latina dieron sobre varias expresiones metafóricas, como “templo de Dios”, “santuario”, “tabernáculo”, “arca”,y otros términos similares referidos a espacios o contenedores reservados a la divinidad. Para abordar este tema, el autor del presente artículo estructura su metodología en tres estrategias fundamentales: el primer paso consiste en un seguimiento sistemático y profundo en fuentes patrísticas y teológicas para detectar declaraciones relevantes de conspicuos maestros de la doctrina cristiana sobre el tema; a través del segundo procedimiento, analiza intra- textualmente cada una de las afirmaciones patrísticas encontradas para descifrar la interpretación doctrinal que cada escritor cristiano aporta sobre tales metáforas; mediante la tercera y conclusiva estra tegia metodológica, el autor relaciona intertextualmente todos estos textos y pensadores a través de un análisis comparativo para resaltar sus posibles concordias o discrepancias. (shrink)

La tendencia natural de identificar complejidad con algo complicado y confuso, es una forma también natural de simplificar las redes complejas del fenómeno del conocimiento y de los saberes. En este artículo se presentan las orientaciones y puntos de partida del pensamiento complejo en la perspectiv..

We seek in this work to make a succinct exposition of the keys of the modal ontology of Leibniz, showing their connection with other modern thinkers; and also to take out to the light some of the problems that the modal metaphysics of Leibniz, in particular about the existential judgment.

Reconocida especialista en el tema, la Dra. Mónica Gordillo accedió a conversar con nosotras a propósito del 50 aniversario del Cordobazo, a pocos días de finalizadas las Jornadas que con el mismo motivo, y bajo su impulso, se celebraron en la ciudad de Córdoba en el mes de mayo de este año.

Fundamento: El currículo de estudios, principalmente de posgrado, no puede considerarse como un plan al que hay que ajustarse de manera estricta, sino que debe ser más flexible, que dé salida a los objetivos propuestos según las situaciones del entorno. Objetivo: mostrar algunos resultados de la vinculación del residente de Higiene y Epidemiología a actividades epidemiológicas emergentes en la actualidad. Método: se realizó un estudio descriptivo transversal en el Centro Provincial de Higiene, Epidemiología y Microbiología de Camagüey durante junio de (...) 2014. Se entrevistó a un universo de 32 profesionales. Las variables utilizadas fueron: utilidad de la vinculación extracurricular a programas y tareas de control epidemiológico, desarrollo práctico de los aspectos teóricos, vencimiento con calidad del diseño curricular de la residencia y si se consideró necesario o no interrumpir el plan de estudios ante eventos epidemiológicos de emergencia. Resultados: La mayoría de los especialistas consideró que la vinculación a actividades específicas le permitió vencer con calidad el plan de estudios, mientras que el mayor porcentaje de los residentes no lo estimó así. Ningún residente entrevistado estuvo de acuerdo con la interrupción del plan de estudios ante situaciones emergentes. Conclusiones: la vinculación del residente a actividades prácticas emergentes puede servir de incentivo para la graduación de un especialista con mayor competencia profesional, sin abandonar el diseño curricular establecido. Fundament: The study curriculum, especially of post grade, cannot be considered as a plan to which one has to be adjusted in a strict way, but to be more flexible, offering a way out to the proposed objectives according to the situations of the environment. Objective: to offer some results of the linking of the medical resident of Hygiene and Epidemiology to emergent epidemiological activities at the present time. Method: A cross-sectional descriptive study at the Provincial Center of Hygiene, Epidemiology and Microbiology during June 2014 was carried out. A universe of 32 professionals was interviewed. The variables used were: usefulness of the extracurricular linking to programs and tasks of epidemiological control, practical development of theoretical aspects, quality achievement of the curricular design of the medical residency, and if it was necessary or not to interrupt the study plan in emergent epidemiological events. Results: Most of the specialists considered the linking to emergent epidemiological activities allowed to finish with quality its study plan, while that the biggest percentage of the residents did not estimate it in the same way. None of the interviewed resident agreed with the interruption of the study plan in front of emergent situations. Conclusions: the linking of the medical resident to practical emergent activities can serve as incentive for the graduation of the specialists with better professional competence without abandoning the established curricular design. (shrink)

The aim of this study was to analyze the explanatory level of the variables advertising influence, verbal messages, social models and social situations as regards body dissatisfaction, weight worry, and bodily discomfort. The study was conducted in a convenience sample of 206 Mexican women with an average age of 22.12 years. Structural equation modeling was used to analyze the direct and indirect effects of the independent variables on the dependent ones in three hypothetical models proposed. In the case of the (...) model proposed for body dissatisfaction, it was found that the set of variables had 79% of variance explained and showed adequate goodness-of-fit indices. The model for weight worry had 62% of variance explained and an acceptable goodness of fit. Finally, the model for bodily discomfort had 72% of variance explained and showed adequate goodness of fit. It is concluded that social influences have a significant impact on body image. Verbal messages had the strongest impact on the variables studied. (shrink)

The debate over judicial review of legislation is profuse. But differences are often due to the lack of a common methodology. This article discusses the proper way to evaluate judicial review and confronts central challenges raised against it. It develops the two main models that can be used for analyzing the intersection between democracy and constitutional decision-making and shows that judicial oversight may not be rejected, regardless of how we interpret that connection. The article discusses in detail the model developed (...) by Jeremy Waldron. A nice attempt to answer methodological questions, Waldron's model wrongly tips the balance against judicial review. Its excessive level of abstraction and idealization renders it inoperable. Few systems meet its standards, and those that do pay a high price: they contradict the concept of democratic legitimacy that underlies the model. Paradoxically, a system with judicial review may end up being more legitimate than one without it. (shrink)

El objetivo principal de este trabajo es dar a conocer en lengua castellana un texto del profesor Thomas Buchheim acerca de la «última prueba» de la existencia de Dios a partir del futurum exactum de su maestro, Robert Spaemann. Para ello se analiza en primer lugar el argumento del futurum exactum del «haber-sido». Seguidamente se exponen las objeciones contra el argumento presentado de esta forma. A continuación, la presentación del argumento a partir del futurum exactum de la verdad. Finalmente se (...) plantean los rasgos personales de la capacidad de verdad que dan pie a considerar la necesidad de una conciencia personal para poder hablar de verdad en sentido propio. (shrink)

La flexibilización de los criterios de demarcación entre la ciencia y la política promovida por los estudios sobre ciencia y tecnología ha dado lugar al desarrollo de un campo de trabajo que explota la noción de «límite» o «frontera». En especial, la literatura sobre «organizaciones fronterizas» ha señalado algunos requisitos de una relación fructífera entre los ámbitos de la ciencia y de la política para la gestión de los problemas a los que se enfrenta la «ciencia post-normal» o «ciencia reguladora (...) » contemporánea. Sin embargo, se olvida a menudo al público no experto en tanto que habitante de estos terrenos fronterizos. En este artículo se hace uso de la terminología derivada de la noción de «trabajo fronterizo» para defender su aplicabilidad a casos de participación pública, y al mismo tiempo se argumenta la necesidad de introducir a la sociedad como uno de los dominios, junto con la ciencia y la política, que se encuentran en las fronteras. (shrink)